How to get started on Makena

Your healthcare provider will determine if you are a candidate for Makena® (hydroxyprogesterone caproate injection) based on the indication for Makena and your current medical need.

Step 1
Your healthcare provider will prescribe Makena:
Learn how Makena is submitted online –or– Learn how Makena is submitted through fax
Learn more
Step 2
Get connected with support programs through the Makena Care Connection®
  • Financial assistance
  • My Adherence Program
  • Makena @Home
Learn more
Step 3
Start therapy on time
  • Expect a call from the Makena Care Connection
  • Shipment confirmed and payment arranged
  • Receive your first injection of Makena
Learn more
Step 1

Your healthcare provider submits a Makena Prescription Form

To prescribe Makena, your healthcare provider will complete the Makena Prescription Form and submit it online or via fax. Take a moment to familiarize yourself with the Makena Prescription Form.

Make sure to sign the Patient Authorization (Step 2 of the form). This allows the Makena Care Connection® to work on your behalf to process your prescription.

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Step 2

Makena helps give baby more time to develop — and offers programs that provide moms an extra layer of support

Get connected through the Makena Care Connection®

Programs that help lower out-of-pocket costs (applies to copays, coinsurance, and deductibles) or provide therapy free of charge for eligible uninsured patients. Learn more

If you are eligible, you can choose to receive your Makena injections in the privacy of your own home from a healthcare professional.
Learn more

A program designed to help you stay on schedule with your weekly Makena injections.
Learn more

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Step 3

Start therapy on time

Expect a call from the Makena Care Connection®:

Once the Makena Care Connection receives your prescription, they will work with you, your healthcare provider, and your insurance company to determine your insurance coverage and out-of-pocket cost.

Calls from the Makena Care Connection will display as "MCC" or a 972 area code on caller ID.


Shipment confirmed and payment arranged:

If Makena is a covered benefit, your insurance-preferred pharmacy will call you to confirm shipment and arrange payment. If you do not receive this call, please call the Makena Care Connection at 1-800-847-3418.

Your prescription cannot ship until you speak with the pharmacy to arrange payment and delivery of the product. The pharmacy’s number may display as an "unknown number" or an 800 number on caller ID.


Receive your first injection of Makena:

A healthcare provider will give you your first injection of Makena anytime between week 16 and week 20, 6 days of your pregnancy.1 This can happen:

  • In the healthcare provider’s office
  • At home through a home nursing service
    • If you would like your injections to be given by a nurse in your home, have your healthcare provider select the Makena @Home option located in Step 4 of your Makena Prescription Form. The Makena Care Connection will investigate your insurance benefits to see if home healthcare administration of Makena is a covered benefit
Watch Makena Care Connection video

The Makena Care Connection® team is here to support you. Find out moreSee more videos

Get to know the Makena Care Connection® team

The manager of the Makena Care Connection introduces her team and explains how they are dedicated to helping you process your prescription for Makena® (hydroxyprogesterone caproate injection) and may lower your out-of-pocket expenses for therapy.

Makena Care Connection prescription process support

Makena Care Connection® assists you throughout the prescription processSee more videos

Makena Care Connection® assists you throughout the prescription process

Get easy-to-follow instructions on completing the prescription process with the help of the Makena Care Connection. Understand the importance of signing the prescription form filled out by your healthcare provider and the importance of answering or returning calls from the Makena Care Connection and/or your pharmacy.



If you have any questions about your Makena prescription, please call the Makena Care Connection (7 am − 7 pm) at 1-800-847-3418 or your assigned pharmacy

Watch Kate discuss Makena Care Connection

Makena Care Connection helped Kate through her prescription processSee more videos

Makena Care Connection® helped Kate through her prescription process

Kate, a busy mother of a toddler, turned to Makena Care Connection when she was pregnant again to help her get started on Makena® (hydroxyprogesterone caproate injection).

Makena patient story
Watch Kate discuss Makena Care Connection

Makena Care Connection® helped Kate through her prescription process

Kate, a busy mother of a toddler, turned to Makena Care Connection when she was pregnant again to help her get started on Makena® (hydroxyprogesterone caproate injection).

Get help paying for Makena

AMAG Pharmaceuticals is fully committed to helping eligible moms access FDA-approved Makena. Our focus includes helping to ensure cost is not a barrier for patient acceptance of therapy. If needed, financial assistance is available for eligible patients.

Watch Makena Copay Assistance Program video

See how the Copay Assistance Program helps commercially insured patientsSee more videos

Learn about Copay Assistance for insured patients

Eligible women can reduce their out-of-pocket cost for Makena® (hydroxyprogesterone caproate injection). Learn about the commitment of AMAG Pharmaceuticals to affordable access to therapy.

Watch Makena Patient Assistance Program video

See how the Patient Assistance Program helps uninsured patientsSee more videos

Learn about Patient Assistance Programs for uninsured patients

Eligible uninsured women can get Makena® (hydroxyprogesterone caproate injection) at no cost. Learn about the commitment of AMAG Pharmaceuticals to affordable access to therapy.

Makena options for insured and uninsured patients Makena options for insured and uninsured patients
  • There are no upper-level income caps—so please, don't assume you are not eligible
  • Each patient's eligibility is evaluated on an individual basis. Program eligibility criteria are subject to change. Financial assistance programs are administered by the Makena Cares Foundation®, which is managed by Sonexus Health.

Eligibility criteria for the assistance programs include:

  • Patient meets the FDA-approved indication (pregnant with a singleton with a history of singleton spontaneous preterm birth before 37 weeks’ gestation)1

In compliance with federal regulations, patients insured by a government-funded program (e.g., Medicaid, TRICARE, etc.) are not eligible.

Makena patient testimonial
Indication

Makena (hydroxyprogesterone caproate injection) is a prescription hormone medicine (progestin) used to lower the risk of preterm birth in women who are pregnant with one baby and who have delivered one baby too early (preterm) in the past. Makena was shown to work based on a lower number of women who delivered babies at less than 37 weeks of pregnancy. There are no studies showing Makena reduces the number of babies who have serious problems shortly after birth or who die. It is not known whether Makena is safe and effective in women who have other risk factors for preterm birth.

Important safety information for Makena (hydroxyprogesterone caproate injection)

Makena should not be used in women with any of the following conditions: blood clots or other blood clotting problems, breast cancer or other hormone-sensitive cancers, or history of these conditions; unusual vaginal bleeding not related to your current pregnancy, yellowing of the skin due to liver problems during pregnancy, liver problems, including liver tumors, or uncontrolled high blood pressure.

Before you receive Makena, tell your healthcare provider if you have an allergy to hydroxyprogesterone caproate, castor oil, or any of the other ingredients in Makena; diabetes or prediabetes, epilepsy, migraine headaches, asthma, heart problems, kidney problems, depression, or high blood pressure.

In a clinical study, certain complications or events associated with pregnancy occurred more often in women who received Makena. These included miscarriage (pregnancy loss before 20 weeks of pregnancy), stillbirth (fetal death occurring during or after the 20th week of pregnancy), hospital admission for preterm labor, preeclampsia (high blood pressure and too much protein in your urine), gestational hypertension (high blood pressure caused by pregnancy), gestational diabetes, and oligohydramnios (low amniotic fluid levels).

Makena may cause serious side effects including blood clots, allergic reactions, depression, and yellowing of your skin and the whites of your eyes. Call your healthcare provider right away if you think you have symptoms of a blood clot (leg swelling, redness in your leg, a spot on your leg that is warm to touch, or leg pain that worsens when you bend your foot) or symptoms of an allergic reaction (hives, itching, or swelling of the face). The most common side effects of Makena include injection site reactions (pain, swelling, itching, bruising, or a hard bump), hives, itching, nausea, and diarrhea.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full prescribing information for Makena.

Reference: 1. Makena® (hydroxyprogesterone caproate injection) prescribing information, AMAG Pharmaceuticals, 2016.

Important safety information and Indication
INDICATION
IMPORTANT SAFETY INFORMATION
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