Learn more about preterm birth and when Makena might be appropriate: videos

If you think you could be at risk for another preterm birth, you're not alone.

Hear from patients who have had a preterm birth before, and what their experience was when using Makena® (hydroxyprogesterone caproate injection) during their next pregnancy. Hear from an obstetrician as he discusses the risks of preterm birth. Learn why FDA-approved Makena may be an option to reduce the risk of preterm birth in certain women who have experienced a prior preterm birth. Plus, learn more about patient assistance programs for Makena.

Patient stories

Watch Kate's video

After speaking with her doctor, Kate made a decision to start Makena® (hydroxyprogesterone caproate injection) because she was at risk for another preterm birth. Hear her story.

Kate gave birth to her son, Gabriel, 5 weeks early (35 weeks). When she became pregnant again a year later, she learned she was at risk for another preterm birth and discussed Makena with her healthcare provider.

Watch Heather's video

Meet Heather. She and her healthcare provider chose an FDA-approved product to help lower her chance of having another preterm birth. Hear her story.

Hear why Heather and her healthcare provider chose an FDA-approved product in her fight against recurrent preterm birth

After giving birth to her daughter Astrid 5 weeks early, Heather’s doctor told her she was at risk for another preterm birth. Heather and her healthcare provider talked about Makena® (hydroxyprogesterone caproate injection) as a treatment option to help give her second baby a better chance to have more time to develop.

Watch Lyn's video

Meet Lyn. Because she delivered her son early, she was at risk for another preterm birth. Hear her story.

Lyn was surprised to find out she was at risk for another preterm birth due to her history, so she decided to take action

After her older son, Lamar, was born 4 weeks early and spent 19 days in the NICU, Lyn wanted to understand what she could do to help improve her chance of achieving a full-term pregnancy with her second child.

Watch Katie's video

Meet Katie. She wanted to do what she could to help reduce her risk of delivering another baby too soon. Hear her story.

Understand why receiving FDA-approved Makena® (hydroxyprogesterone caproate injection) was important to Katie

When Katie's water broke unexpectedly at 34 weeks with her first child, she wasn't prepared. Katie wanted to do what she could to help reduce her risk of delivering another baby too soon.

About preterm birth

Watch an Ob/Gyn discuss Makena

Have you delivered preterm (before 37 weeks) in the past? Listen to an obstetrician to learn more.

Dr. Gandell, a practicing obstetrician for 31 years, explains preterm birth, its risk factors, and how Makena® (hydroxyprogesterone caproate injection) may be able to help reduce the risk of recurrent perterm birth.

Watch preterm birth risk factors video

Kate and her healthcare provider discuss her risk for another preterm birth and how she can reduce her risk for another preterm delivery

Once Kate found out she was pregnant again, she scheduled an appointment with her doctor to discuss her risk for another preterm birth and how Makena® (hydroxyprogesterone caproate injection) may help reduce her risk.

Watch a video on benefits of FDA approval

Understand the benefits of taking an FDA-approved medication

Jennifer Gudeman, PharmD, Executive Director of Medical Affairs, describes the FDA’s statement that FDA-approved medications should be used when medically appropriate rather than compounded formulations, unless there is a specific medical need for the patient.

Watch a video about FDA-approved drugs vs compounded drugs

Are compounded products and generic medications the same?

Are compounded products and generic medications the same?

Jennifer Gudeman, PharmD, Executive Director of Medical Affairs, describes the differences between FDA-approved drugs (brand and generic) made in accordance with Good Manufacturing Practices (GMPs) and compounded drugs made in a pharmacy.

Watch a video about the FDA statement about hydroxyprogesterone caproate

Learn about the FDA statement regarding hydroxyprogesterone caproate

The benefits of FDA approval

Jennifer Gudeman, PharmD, Executive Director of Medical Affairs, discusses the differences between FDA-approved medications and treatments that are compounded at pharmacies, and why the FDA recommends using FDA-approved products when medically appropriate.

Watch Makena potential side effects video

Review most common and most serious side effects potentially associated with use of Makena

What are the potential side effects of Makena® (hydroxyprogesterone caproate injection)?

It's understandable to have a lot of questions about taking a medication while pregnant. Learn more about what to expect when receiving Makena injections so you and your healthcare provider can discuss if Makena is right for you.

Watch a video that discusses who might benefit from treatment

See if you may be a candidate for Makena and talk to your healthcare provider to see if Makena is right for you

Find out if Makena® (hydroxyprogesterone caproate injection) is right for you

If you have delivered a baby too early in the past, you are at an increased risk for another preterm birth. Find out if Makena may be right for you.

Watch a video explaining what to expect during your Makena injection

What to expect during your Makena injection

Understand how your healthcare provider gives a Makena injection

Nurse Kristina explains what to expect during your Makena injection that is given by a healthcare provider.

Support programs

Watch Kate discuss Makena Care Connection

Makena Care Connection® helped Kate through her prescription process

Kate, a busy mother of a toddler, turned to Makena Care Connection when she was pregnant again to help her get started on Makena® (hydroxyprogesterone caproate injection).

Watch a video about the Makena Care Connection team

Makena Care Connection® assists you throughout the prescription process

Get to know the Makena Care Connection® team

The manager of the Makena Care Connection introduces her team and explains how they are dedicated to helping you process your prescription for Makena® (hydroxyprogesterone caproate injection) and may lower your out-of-pocket expenses for therapy.

Watch a video about the Makena Patient Assistance Program

Learn about financial Patient Assistance Programs for uninsured patients

Learn about Patient Assistance for uninsured patients

Eligible uninsured women can reduce their out-of-pocket cost for Makena® (hydroxyprogesterone caproate injection). Learn about the commitment of AMAG Pharmaceuticals to affordable access to therapy.

Watch a video about the Makena Copay Assistance Program

Learn about Copay Assistance for insured patients

Eligible women can reduce their out-of-pocket cost for Makena® (hydroxyprogesterone caproate injection). Learn about the commitment of AMAG Pharmaceuticals to affordable access to therapy.

Watch a video about Makena Care Connection prescription process support

The Makena Care Connection® team is here to support you. Find out more.

Makena Care Connection® assists you throughout the prescription process

Get easy-to-follow instructions on completing the prescription process with the help of the Makena Care Connection. Understand the importance of signing the prescription form filled out by your healthcare provider and the importance of answering or returning calls from the Makena Care Connection and/or your pharmacy.

Indication

Makena (hydroxyprogesterone caproate injection) is a prescription hormone medicine (progestin) used to lower the risk of preterm birth in women who are pregnant with one baby and who have delivered one baby too early (preterm) in the past. Makena was shown to work based on a lower number of women who delivered babies at less than 37 weeks of pregnancy. There are no studies showing Makena reduces the number of babies who have serious problems shortly after birth or who die. It is not known whether Makena is safe and effective in women who have other risk factors for preterm birth.

Important safety information for Makena (hydroxyprogesterone caproate injection)

Makena should not be used in women with any of the following conditions: blood clots or other blood clotting problems, breast cancer or other hormone-sensitive cancers, or history of these conditions; unusual vaginal bleeding not related to your current pregnancy, yellowing of the skin due to liver problems during pregnancy, liver problems, including liver tumors, or uncontrolled high blood pressure.

Before you receive Makena, tell your healthcare provider if you have an allergy to hydroxyprogesterone caproate, castor oil, or any of the other ingredients in Makena; diabetes or prediabetes, epilepsy, migraine headaches, asthma, heart problems, kidney problems, depression, or high blood pressure.

In a clinical study, certain complications or events associated with pregnancy occurred more often in women who received Makena. These included miscarriage (pregnancy loss before 20 weeks of pregnancy), stillbirth (fetal death occurring during or after the 20th week of pregnancy), hospital admission for preterm labor, preeclampsia (high blood pressure and too much protein in your urine), gestational hypertension (high blood pressure caused by pregnancy), gestational diabetes, and oligohydramnios (low amniotic fluid levels).

Makena may cause serious side effects including blood clots, allergic reactions, depression, and yellowing of your skin and the whites of your eyes. Call your healthcare provider right away if you think you have symptoms of a blood clot (leg swelling, redness in your leg, a spot on your leg that is warm to touch, or leg pain that worsens when you bend your foot) or symptoms of an allergic reaction (hives, itching, or swelling of the face). The most common side effects of Makena include injection site reactions (pain, swelling, itching, bruising, or a hard bump), hives, itching, nausea, and diarrhea.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full prescribing information for Makena.

Important safety information and Indication
INDICATION
IMPORTANT SAFETY INFORMATION
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